http://www.ishiilab.org/home daily 0.75 2017-02-27 http://www.ishiilab.org/home-wip daily 0.75 2017-02-27 http://www.ishiilab.org/new-page daily 0.75 2022-07-18 https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/465b4484-a604-4192-a61f-52bac75c73a3/3FBB18B9-1FF8-44F3-A2E9-78AD54ADB1DC.jpeg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/32c63f57-f784-49a5-ad92-5ef5168183b7/IMG_6475+%281%29.jpg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/180ee4ce-bd40-4b4e-94b2-9c394c18ff03/euduardo.png Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/41fd7902-c033-4d1d-a616-b23fd95adc41/B957E714-9731-4375-B868-1FBAE7BEE8B4.jpeg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/54b36755-1726-43cb-a1f5-54fe2115332a/IMG_8097.JPG Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/be4594e6-9742-4f90-8bf0-715ab10ec08e/C320513D-97F9-4BDF-BE81-963E92FB42E8.jpeg Our Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/1476730896518-YB6U57JNSQWBBHZ46LNL/image-asset.jpeg Our Team http://www.ishiilab.org/home-1 daily 1.0 2022-07-15 https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/1522268073345-T2MBVINIDJ3CX2B7372W/fig1bbabodyweightdementia.jpg Ishii Lab Figure 1: The relationship between body weight/adiposity and age-related dementia (Adapted from Ishii and Iadecola, Biochimica et Biophysica Acta Molecular Basis of Disease 2016) https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/1488231602508-GJK8HMEUFLSL3P7EHMT7/F1.large.jpg Ishii Lab http://www.ishiilab.org/read-me daily 0.75 2017-02-27 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390928870858-4D9B6T9WGP8017NSS9W3/topography.jpg Contact Us http://www.ishiilab.org/research-interests daily 0.75 2020-09-23 https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/1522266257413-ASY27UQYUQ3QL6HMB9NF/fig4npygfppatch.jpg Research Interests Figure 4: GFP labeled NPY neurons in the arcuate nuclei of the hypothalamus are evaluated by whole-cell patch clamp (with collaborator Dr. Gang Wang, BMRI). https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/1522267205928-U5UXDD5Z1RPPI8BF1N47/fig5schematic.jpg Research Interests Figure 5: Schematic of a proposed pathophysiological mechanism for amyloid-beta mediated inhibition of hypothalamic pathways leading to weight loss and a low leptin state. (Adapted from Ishii et al., J Neuroscience 2014) https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/1522265924372-HFWVT806JDYJ8OCT4N52/fig2bodyweightleptin.jpg Research Interests Figure 2: Deficits in body weight and plasma leptin levels worsen with increasing age and brain amyloid-beta brain burden in a transgenic mouse model overexpressing the amyloid precursor protein (Adapted from Ishii et al., J Neuroscience 2014) https://images.squarespace-cdn.com/content/v1/57fe3d97ff7c50274b161612/1522265960795-55PRM7G110T57JICV98G/fig3mriwtvstg2576.jpg Research Interests Figure 3: 3 month-old transgenic mice over-expressing amyloid precursor protein (Tg2576) have significantly lower body adiposity (white hyper-intense signals on T1-weighted MRI) compared to wild-type (WT) littermates. (Adapted from Ishii et al., J Neuroscience 2014) http://www.ishiilab.org/for-prospective-patients daily 0.75 2020-09-23 http://www.ishiilab.org/home-alt-bedford daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500612440-PGQSIY8KL9F7T5VIXQLO/chambers-2.jpg Home Alt A better world Starts with a choice Contact Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500503574-5BAPXZO9U06UV61P49UO/chambers1.jpg Home Alt Sustainability Starts with you Join Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390500933384-LII4SRIPHFYOUFX0UCXC/chambers-4.jpg Home Alt A better world Starts with a choice Join Us https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390504287124-HQ8GNX1JCE22V047MSQ9/chambers-8.jpg Home Alt Preserve Nature Join Us